Nirmatrelvir with ritonavir (Paxlovid®) is now available for patients with COVID-19 who are at high risk of severe disease. This bulletin discusses drug interactions that can occur with ritonavir, some of which may be potentially life-threatening.

Further information on use of Paxlovid® can be found at:

• Ministry of Health – Therapeutics for the treatment of COVID-19
• HealthPathways – HealthPathways>COVD-19 Case Management In Adults>COVID-19 Specific Therapies>Paxlovid (nirmaltrevir with ritonavir)
• He Ako Hiringa – Treating COVID-19 with Paxlovid in primary care

Health professionals are welcome to contact our service for more specific advice on individual patients.