Bulletins - Other
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AdministrationAdverse drug reactionsCannabis-based productsComplementary and Alternative Medicines (CAMs)COVID-19Drug comparisonsInteractionsNew medicineOtherPharmacokineticPregnancy/BreastfeedingAssessing medicines when stored outside manufacturer recommendations - August 7, 2024
Storage of medicines per manufacturers’ specifications ensures medicines are fit for purpose. If stored outside these specifications, or used beyond the expiry date, medicines may be less effective, and/or have increased toxicity. This bulletin provides a framework for considering whether medic...
Medicines and Meals – Food for Thought? - June 24, 2024
The timing of medicine administration in relation to food is not important for most medicines. In general, patients should be advised to take their medicines consistently at the same time with respect to meals.
Adherence to medicines is a primary determinant of treatment success.
Poor adh...
Analgesia during pregnancy or while breastfeeding - July 5, 2023
Treatment of pain in pregnant and breastfeeding women should follow the same principles as for all adults, using the analgesic ladder:
Step 1: Paracetamol and/ or NSAID, e.g. ibuprofen or diclofenac
Step 2: Add a weak opioid for mild to moderate pain, e.g. codeine, tramadol
Step 3: Chang...
Crushing nirmatrelvir+ritonavir (Paxlovid®) tablets - December 22, 2022
Background
Pfizer state in their prescribing information that both nirmatrelvir and ritonavir tablets should be swallowed whole and not chewed, broken, or crushed. [1] This is due to a lack of pharmacokinetic data to support administration in this manner. However, a Phase 1 study with a nirmatre...
Pharmacokinetic medicines interactions with probenecid - November 29, 2022
Probenecid was introduced in the 1950’s to reduce the renal elimination and extend the plasma half-life of penicillins. This effect is exploited therapeutically in the treatment of cellulitis and other infections. It is also used for gout prophylaxis, in light of its uricosuric effects.
Prob...
Morphine and Oxycodone – Similarities and Differences - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate
Prescribing in Patients with Frailty - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate
Herb Drug Interactions - August 17, 2022
Note this bulletin is older than 5 years old and the content may no longer be accurate